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Archive for February, 2010

Romantic Games - Bring A New Level of Passion

Saturday, February 27th, 2010

Fanciful Games - Conspicuous A Original Play fair with of Passion

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Even the most passionate couples can use a little innovation and fun in the bedroom. Busy schedules, familiarity and the everyday demands of life can leave things feeling a little too comfortable. However, it’s not difficult to breathe new life into intimate encounters. Trying new things, and perhaps being a little adventurous can make things feel brand new again. Romantic Games designed specifically for couples, can make things fun and exciting again. I would recommend Nookii which is geared toward couples looking for new ways to explore each other.

I feel that true sexual enjoyment is more than just an occasional event, it’s a way of life. Sex is a central part of our lives, and influences our lives in countless ways, from the decisions we make to the people we partner with. Sex isn’t supposed to be taboo, or guilt-inducing, it should be fun, fulfilling, and liberated. To this end, select products that are meant not just to improve your sex life, but to make you feel more confident in your sexuality, and follow a truly sinless way of life. Whether you’re searching for sensual lingerie, exciting romantic games or DVDs and books, the products should be liberating as they are sexual.

Some of the things I could suggest would be to have some fun with food. Try some flavored body paint and see what kind of masterpieces you and your partner can create on each other. See what ideas you can think of with common food items such as honey, chocolate syrup or whipped cream. Another would be to get playful with sexy costumes . Try some creative role-playing. Try using nurse costumes or French maid costumes The possibilities are only limited by your imagination. Think of it as acting, watch it unfold and see if you end up in a very X-rated place.

People use romantic games for many reasons. It might be to bring flair to a comfortable relationship where the bright fire of passion has ebbed, or to experience new adventures with a new partner. Although the definition of sexual freedom varies from one individual to the next, the true heart of liberation is feeling free to pursue the experiences that you are comfortable with. When sex is shared between two willing adults, there’s no reason to feel guilty or ashamed.

New Data Reinforce One In Three Rheumatoid Arthritis (RA) Patients Achieve Clinical Remission With Tocilizumab

Friday, February 26th, 2010

Exciting new data from the TOWARD go into, at the American College of Rheumatology (ACR) Annual Methodical Meeting in Boston, clarify that around one in three patients achieved clinical remission in the tocilizumab (Actemra) faction, as assessed using DAS28

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People ages 57 to 85 think of sexuality as an important part of life

Wednesday, February 24th, 2010

The initial thorough national survey of sexual attitudes, behaviors and problems number older adults in the Mutual States has found that most people ages 57 to 85 think of sexuality as an important part of vitality and that the frequency of sexual vigour, for those who are potent, declines only slightly from the 50s to the primordial 70s.

Data from the University of Chicago’s National Social Life, Health and Aging Project (NSHAP), presented in the August 23, 2007, issue of the New England Journal of Medicine, showed that many men and women remain sexually activeparticipating in vaginal intercourse, oral sex and masturbationwell into their 70s and 80s.


The survey also found that sexual activity was closely tied to overall health, which was even more important than age. As health declined steadily after the early 70s, so did the prevalence of sexual activity, particularly for women. Among those who remained sexually active, nearly half reported at least one sexual problem, such as lack of desire (43% of women), vaginal dryness (39% of women) or erectile dysfunction (37% of men).


“We found that older adults remain interested and engage in sex, yet many experience bothersome sexual problems that can compromise both health and relationships,” said Stacy Tesser Lindau, MD, assistant professor of obstetrics and gynecology and of medicine-geriatrics at the University of Chicago and lead author of the study.


With the first baby boomers turning 60, older adults make up the fastest growing segment of the US population. Yet the “lack of reliable information about how sexual activity and function might change with age and illness, combined with taboos around discussing sex in later life, contributes to worry or even shame for many older adults,” she added.


“I am especially happy that we now have in hand reliable and comprehensive information on sexual function and activity among older adults based on a scientifically drawn representative sample of Americans 57 years of age and older,” said co-author Edward Laumann, PhD, the George Herbert Mead Distinguished Service Professor in Sociology and co-director of the 1992 National Health and Social Life Survey, which surveyed persons aged 18 to 59.

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“Social relationships are known to contribute to health and well-being in older men and women,” says Richard Suzman, PhD, director of the Social and Behavioral Research Program at the National Institute on Aging, which primarily funded the study. “This pioneering research gives us valuable insight into intimate social relationships, providing data clinicians may now draw upon to open better informed conversations with patients about sexuality and health.”


Many medical conditions and treatments can interfere with sexuality. American men spend more than a billion dollars each year on medications to improve sexual function. Despite such frequent problems, few older men (38%) and even fewer women (22%) had discussed sex with a physician since age 50, the researchers found. Men were more likely to do so, perhaps because effective drugs are available. Nearly 1 in 7 men (14%) reported taking medication to improve sexual function.


The survey documented another significant gender difference. While 78 percent of men ages 75 to 85 have a spouse or other intimate relationship, only 40 percent of women that age do, a consequence of the age disparity of relationships coupled with women’s greater longevity.


“Sexuality is an important part of a healthy and engaged life at older ages for both women and men,” said co-author Linda Waite, PhD, the Lucy Flower Professor in Urban Sociology at the University of Chicago and Director of the Center for Aging at NORC. For the vast majority of men, aging is a partnered experience, “but women’s sexuality,” Waite said, “is more often affected by the death or poor health of their spouse.”


NSHAP, funded by the National Institutes of Health, was created to discover how social relationships, especially intimate relationships, influence health as people age. Between July 2005 and March 2006, the researchers interviewed 3,005 people ages 57 to 85 in their homes. They asked about social and marital history, sexual activity and function, and physical and mental health.


While there have been other surveys focused on the older population, “they have typically been based on convenience samples with low completion rates or clinical samples with unknown biases in representing the population at large,” Laumann said. Such surveys typically over- or under-estimate the prevalence of sexual problems. “NSHAP provides us with a much more reliable guide to strengths and weaknesses of sexual health in the older population of the United States.”


Another new element of NSHAP is the collection of physiological specimens such as spots of blood, saliva and vaginal swabs. In follow-up studies, the researchers will use these specimens to extract various “biomarkers.” These will provide evidence about hormone levels, prevalence of diseases such as heart disease or diabetes, and the frequency of human papillomavirus, a sexually transmitted disease.


The NSHAP team also gathered data on how older adults perceive the world of social relationships, assessing participants sense of touch, taste and smell as well as vision and hearing.


Despite the personal nature of many of the questions, study participants were very forthcoming, as expected from prior clinical and research experience with older adults. Seventy-five percent of those approached agreed to participate. Overall, only 2 to 7 percent declined to answer direct questions about sexual activities or problems. (Fourteen percent did not answer questions about masturbation on a self-administered questionnaire.) Participants were more likely to refuse questions about income than they were about sex, Lindau said.


Many of those who were sexually active found ways to remain active, despite worsening health. The proportion of sexually active couples that engage in oral sex, for example, hovered at around 50 percent for those under 75. More than half of men and a quarter of women, whether they had a sexual partner or not, acknowledged masturbating.


“Although sexuality has long been thought to deteriorate inevitably with age, we found that health is a more important indicator for many aspects of sexuality than is age alone,” Lindau said. “This suggests that older adults with medical problems, or those considering treatment that might affect sexuality, should be counseled based on health status rather than just their age.”


The most common reported reason for sexual inactivity among individuals with a spousal or other intimate relationship for men (55%) and women (64%) was the male partner’s physical health. Women, especially those who were not in a current relationship, were more likely than men to report lack of interest in sex.


Despite the unprecedented shift in the age of the population, the public, physicians and policymakers lack information on sexual behavior at older ages and on how sexual activities and problems change with age and illness.


“We hope our findings improve public health by countering harmful stereotypes and allowing older individuals to view their experience relative to others,” Lindau said. “It may comfort people to know that they are not alone in enjoying sexual activity as they age or in experiencing sexual problems, some of which could be alleviated with medical attention.”


This report, according to the authors, provides the first such reference for clinical decision making. It “should improve patient education and counseling,” they conclude, and help identify “health related and potentially treatable sexual problems.”


http://www.uchospitals.edu

Terrorist Attacks Associated With Heart Problems In Individuals Who Experienced Severe Stress

Sunday, February 21st, 2010

A person who experienced severe stress-mutual symptoms straight after the September 11 desperado attacks in the USA has a higher gamble of being diagnosed with heart/cardiovascular problems during the subsequent three years, says an article in Archives of General Psychiatry (JAMA/Archives).

The researchers explain “Extremely stressful events may precipitate biological processes that increase one’s risk of developing cardiovascular ailments. While acute stress may trigger immediate potentially fatal cardiovascular responses, sudden, subacute and chronic stress can evenly prolong cardiovascular risk through neurohormonal arousal. This physiologic reactivity may be easily rekindled by trauma reminders, leaving individuals exposed to the detrimental effects of arousal upward of time.”

E. Alison Holman, F.N.P., Ph.D., University of California, Irvine, and troupe looked at 2,729 adults, of whom 2,592 (95%) had completed an online health assessment prior to 9/11. Nearly 9-14 days after the attacks they took separate in a web-based survey which asked them thither their acute importance responses, such as anxiety, feelings of detachment from the world and/or themselves (dissociative symptoms), or re-experiencing the disturbance. They were all re-surveyed each year on the side of the next three years.

Three years after the attacks, the participants who had been diagnosed with a heart ailment rose to 30.5% from 21.5%. The researchers pen “Acute stress responses to the 9/11 attacks were associated with a 53 percent increased amount of cardiovascular ailments over the three subsequent years, even after adjusting for pre-9/11 cardiovascular and crazy health status, position of jeopardy to the attacks, cardiovascular endanger factors (i.e. smoking, firmness heap up indication and swarm of endocrine ailments), comprehensive number of physical health ailments, somatization (the conversion of psychological symptoms into carnal symptoms) and demographics”.

Those who had reported costly levels of acute stress straight after the attacks seemed to have insincere the risk of being diagnosed with stiff blood pressure (hypertension) and three times the chances of reporting a diagnosis of heart problems during the 36 months after the attacks. The researchers write “Among individuals reporting ongoing worry with reference to terrorism register-9/11, high 9/11-related clever accent symptoms predicted increased risk of physician-diagnosed nerve problems two to three years following the attacks,”

The researchers concluded that keen stress reactions may be predictors of subsequent serious health problems.

“Terrorism, Acute Stress, and Cardiovascular Health. A 3-Year National Exploration Following the September 11th Attacks”
E. Alison Holman, FNP, PhD; Roxane Cohen Silver, PhD; Michael Poulin, PhD; Judith Andersen, PhD; Virginia Gil-Rivas, PhD; Daniel N. McIntosh, PhD
Greatest Gen Psychiatry. 2008;65(1):73-80.
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Written by - Christian Nordqvist

Copyright: Medical News Today

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Not to be reproduced without permission of Medical News Today

Vasogen’s Celacade(TM) Shown To Significantly Reduce Time In Hospital In Prime Heart Failure Target Population

Thursday, February 18th, 2010

Vasogen Inc. (NASDAQ:VSGN; TSX:VAS), a leader in the inspection and commercial development of technologies targeting the continuing inflammation underlying cardiovascular and neurological disease, today announced that new details from the 2,400-patient ACCLAIM trial of Celacade in chronic empathy default, showed that the average days out in hospital for cardiovascular cause was reduced by 32% in a prime heart failure target population, consisting of Supplemental York Centre Association (NYHA) Category II-IV non-ischemic cardiomyopathy patients, characterized as having no prior past of goodness attack, and Savoir faire II patients with ischemic basics failure (n=1,305 patients, p=0.013).

The results were presented today by Guillermo Torre-Amione MD, PhD, at the 10th Annual Scientific Engagement of the Heart Flop People of America in Seattle, Washington. Chronic heart default is estimated to cost the healthcare system $25 billion annually in the U.S., and recurring hospitalizations are the major cost driver.

“The ability of Celacade to significantly reduce for the moment in hospital, in conjunction with reducing the risk of death or cardiovascular hospitalization as a remedy for this momentous gathering of heart ruin patients, underscores the robustness and consistency of the ACCLAIM data,” stated Dr. Torre-Amione, Medical Director, Heart Uproot Program, Methodist DeBakey Heart Center at The Methodist Hospital, and Principal Investigator in the service of the U.S. arm of the ACCLAIM trial. “The need for the sake of repeated hospitalizations remains a persistent problem as a service to focus failure patients, resulting in reduced grandeur of life and a major drain on healthcare resources. A treatment that not only reduces the jeopardy of passing or first cardiovascular
hospitalization, but also reduces the total days spent in hospital by a similar importance, would be a welcome withal to the standard of care.”

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As presented by Dr. Torre-Amione today, a combined interpretation of NYHA Merit II-IV non-ischemic cardiomyopathy patients, characterized as having no one-time history of heart wasting, as healthy as Descent II patients with ischemic etiology, demonstrated a 31% reduction in the peril of death or first cardiovascular hospitalization in the Celacade group compared to placebo (n=1,305 patients, 391 events, p=0.0003). Novel information presented today showed that, in these patients, Celacade also reduced total days in hospital for cardiovascular cause by 32% (n= 1,305 patients, p=0.013).

A combined analysis based on pre-specified subgroups, which excluded at most those patients in NYHA Class III/IV with a red-ventricular ejection fraction brother to or below the median (LVEF

New Paradigm For Medicinal Chemistry Offered By International Public-Private Partnership

Tuesday, February 16th, 2010

The Wellcome Trust has announced a £4.1 million investment in a new drive to bring into being small molecule inhibitors - “chemical probes” - for 25 proteins affected in epigenetic signalling, and to release these probes into the exposed domain with no restriction on use. At the crack stage information sharing on chemical probes is tremendously unusual and breaks with the institution of keeping such data confidential.

The public-private partnership, to be led by the Structural Genomics Consortium (SGC), also involves GlaxoSmithKline (GSK), the Governmental Institutes of Health Chemical Genomics Center (NCGC) in Bethesda, USA, and the Departments of Chemistry and Biochemistry at the University of Oxford. The dynamism could propose a inexperienced model for the benefit of future interactions between academia and industry.

The study of epigenetics tries to informed heritable changes in gene function that occur without a change in the DNA string. This signalling is thought to weight the timing, amount and type of proteins made by genes: In diseases these proteins can be altered, for instance, in tumour cells particular proteins are often present at much higher levels than in reasonable cells. Researchers believe that by identifying how these parameters are controlled, they can better understand the factors that lead to many general diseases, such as cancer, diabetes, obesity and Alzheimer’s disease.

The SGC-led drive aims to blossom “chemical probes”, small molecules that can quicken or brick the activity of a protein, specifically designed to affect the vocation of proteins labyrinthine associated with in epigenetic in check. They will complement genetic knockouts and RNAi approaches to understand the role of these proteins in biology. The probes miss to be highly selective for their butt protein, and suitable for use in cellular settings. It is hoped that some probes may be a starting detail for stimulant discovery.

The partnership is unique in that it brings the medicinal chemistry know-how within production together with the biological skill within academia to speak an emerging area of biology. In this care, the initiative may provide an but for the fact that poser on account of future interactions between academia and labour in the area of “pre-competitive chemistry”.

“Well characterised chemical probes are hugely valuable conducive to target validation and exploration of biology,” said Dr Patrick Vallance, senior vice-president of Drug Detection at GSK. “This link between the academic community and GSK in an emerging area of science should enhance education and ultimately support our efforts to develop more medicines of benefit to patients.”

In keeping with SGC policy, the structure and function of each probe will with alacrity be made freely available. Traditionally, pharmaceutical compounds compel ought to ordinarily only been released for public use after the relevant poison event program has been completed. It was thought that releasing an old-devise inhibitor would hamper further research in the corresponding neighbourhood by the pharmaceutical sector, but news shows that the pharmaceutical manufacture is far more odds-on to conduct a drug discovery programme if there are already far-characterised inhibitors with defined mechanisms of effect elbow.

The NCGC, led by its leader, Dr Christopher Austin, will make particular contributions to the project, from assay development to excessive-throughput screening to analeptic chemistry.

“This is a unique collaboration bringing together the chemistry mightiness of a large pharmaceutical company with cutting edge activities in the erudite sector to deliver chemical probes to the broad systematic community,” says Dr Chas Bountra, Chief Scientist at SGC in Oxford. “I believe this volunteer creates a paradigm shift as GSK opens up its internal chemistry capability to think up new chemical probes that can be unobstructedly used by all academic and industrial scientists.”

“Industry and academia both stand to extras from this relationship,” says Dr Alan Schafer, Head of Molecular and Physiological Sciences at the Wellcome Conglomerate. “The hypothetical community will take access to the sophisticated research tools predominantly only available to industrial partners, and the resultant application in idealistic research will dish up to more distant awaken drug development by pharmaceutical companies. In the end this is beside enabling the transmission of biomedical investigating discoveries into therapies for the benefit of patients.”

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Article adapted by Medical Press release Today from primary converge release.
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Source: Craig Brierley

Wellcome Safe keeping

ImQuest Publishes Results Of Important Structure Activity Relationship Program On Dual Acting Pyrimidinediones

Saturday, February 13th, 2010

ImQuest BioSciences, Inc.
announced the publication of the results of an important configuration-
interest relationship study to investigate the efficacy and toxicity of a
series of pyrimidinedione analogs against HIV-1 and HIV-2. The manuscript,
published in the journal Antiviral Chemistry and Chemotherapy, shows the
results of ImQuest’s HIV hallucinogenic development program based on compounds which
it licensed from Samjin Pharmaceutical Co. Ltd. The report, authored by
Robert W. Buckheit, Jr., Ph.D. (Executive Vice President and Chief
Scientific Apparatchik of ImQuest) describes the synthesis of the highly effective
pyrimidinedione series and the structural features of the compounds which
are responsible for their high level of potency against HIV, the expanded
range of action to include HIV-2, and the one and only dual mechanism of entry
and RT inhibitory activity against HIV-1.

“The studies performed resolution allow us to focus our resources on the
preclinical and clinical development of the most formidable lead
pyrimidinedione and to gain insight into the molecular features of the
compounds which production the high potency and representative dual mechanism of
antiviral fighting of these unique compounds,” explained Dr. Buckheit. Other
coauthors on this credentials include ImQuest virologists Tracy Hartman, Karen
Watson and Lu Yang and Samjin chemists Ho-Seok Kwon, Miscellany-Hwan Lee,
Jae-Woong Lee, Dong-Wook Kang, Sun-Gan Chung and Eui-Hwan Cho.

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ImQuest expects to submit an IND to initiate Phase 1 human clinical
trials with IQP-0410, a highly potent member of the pyrimidinedione series
in the third quarter of 2008. In totting up, ImQuest has initiated
IND-enabling studies with the pyrimidinedione IQP-0528 as a potential
anti-HIV contemporary microbicide.

ImQuest Life Sciences, a privately held U.S. company located in
Frederick, Maryland specializes in early stage drug development of novel
compounds in place of the treatment of infectious disease and cancer. Samjin
Pharmaceutical Co., a publicly held actors listed on the Korean Roots
Quarrel, is individual of the leading pharmaceutical companies in Korea. ImQuest
BioSciences, also located in Frederick, Maryland, is a outstanding provider of
anti-infective and anti- cancer drug and vaccine development services to
the biotechnology and pharmaceutical commerce.

ImQuest BioSciences, Inc.
http://www.imquest.com

First UK Study To Determine How General Practice Professionals Can Tackle Adolescent Obesity

Thursday, February 11th, 2010

Academics at the University of Hertfordshire are conducting the beforehand UK swotting to investigate how healthiness professionals based in usual day-to-day can help adolescents who are obese to lose onus.

The examination which the University has announced during Obesity Awareness Week, and wish be conducted over a three-year while, will view GPs and study nurses working in general practices in Hertfordshire and Bedfordshire regarding their current habit in the direction of adolescents who are corpulent.

It order look at their attitudes towards and unrealized barriers to giving weight management warning to teenaged people and their awareness of and opinions on existing guidelines.

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Ms Josefine Magnusson at the University’s Centre for Primary and Community Care (CRIPACC) said: “A search of the existing literature found no UK-based studies on how this issue is managed in regular practice. Much of the digging on obesity and overweight young people has focused on younger children rather than adolescents and few studies have been done in the UK.”

The turn over will go on to examine a sub-sample of the health professionals surveyed in bid to gain a more in-abstruseness perspective of the Dialect heft directorate services they offer to young people.

During the later stages of the sanctum sanctorum, adolescents (aged 13-16) who are pot-bellied ordain be interviewed about their experiences with such services and the associated dormant barriers and facilitators. The parents of those adolescents require also be interviewed on their experiences of, and/ or attitudes towards, overall practice as a mounting for manipulate conduct advice through despite young people.

Ms Magnusson commented: “The outcomes of this research will upon what in circulation practice of dealing with tubby adolescents in general practice is; what the dormant barriers also in behalf of implementing general way-based interventions authority be, and a health professional and litter person’s perspective on how these services can paramount be utilised. It is unlikely that any general practice-based interventions aimed at helping obese adolescents to squander weight last wishes as be affluent before these points are fully investigated.”

HERTFORDSHIRE UNIVERSITY
College Lane
Hatfield
Herts
AL10 9AB
http://www.herts.ac.uk

At home with Microdermabrasion

Tuesday, February 9th, 2010

Tired of dull, saggy incrustation that makes you feel old? Period imagined frustrating the same ‘instant facelift’ Hollywood celebrities see? Profoundly, it’s time to start now that microdermabrasion is at one’s fingertips at home! You can pamper yourself the fashion Kate Moss, Madonna, Uma Thurman, Cindy Crawford, Gwen Stefani and Cameron Diaz do without making a huge dent in your budget!

So what exactly is microdermabrasion? And how does it work for you? For starters, it’s a great alternative to costly and invasive cosmetic procedures like Botox, chemical peels and plastic surgery. It gives your skin a fresh glow by reducing fine lines, acne marks, clogged pores and oily skin. And the best part is it’s painless!

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This treatment, also called the lunchtime peel since it takes about 30 minutes, removes dead skin cells through particle resurfacing. You will notice smooth glowing skin instantly after the first session itself. Over time, there will be a marked improvement in fine lines and scars. Microdermabrasion works especially well on acne. In case you’re wondering how come it works on young skin dotted with acne and older skin sketched with wrinkles? It does by simply removing the topmost layer of one’s skin, making it possible to smoothen out wrinkles, scars and other skin imperfections.

What happens is a machine is used to apply tiny rough grains that gradually scrape away the skin’s surface. It can be used on the face, neck, chest, back, feet and hands. This microdermabrasion machine has a compressor and pump that mixes gentle abrasion with suction to remove the skin’s dead cells. This makes the skin regenerate its cells faster leading to a more youthful looking skin.

As you can see the benefits of microdermabrasion are plenty: • Revitalizes dull skin • Gives a more even skin tone • Reduces stretch marks, mild pigmentation, enlarged pores • Erases acne marks, fine lines and wrinkles • Reduces the harmful effects of the sun & pollution • No anaesthesia is used • It works on any skin tone and hardly needs any recovery time

As a matter of fact, unlike other skin procedures, it lets you get back to your routine after one hour. After the first session you will notice a mild swelling and redness. Depending on your skin type, these effects will wear away after an hour or maximum one day.

You may find your skin peeling after this treatment, that’s why you must always use a sun screen and moisturizer after each session. Actually, it’s best to avoid the sun for at least 24 hours. Since the topmost layer of your skin has been exfoliated, the treated area will be a little sensitive on the first day. But as a trade off, the skin’s texture would have improved and advanced skin care products will be more effective now that they can easily penetrate into the deeper layer of the skin. This will stimulate collagen production over time, giving you a distinctly youthful appearance!

For this treatment to be effective in the long run you will need multiple sessions. Six sessions are recommended every 2 weeks for long lasting results. But doing it in the comfort of your house makes it less daunting. No commuting. No appointment making. No waiting rooms. Just you and your dependable machine! And you won’t be burning a hole in your pocket by paying $75 to $150 for each treatment at a spa or dermatologist’s office!

Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Submits New Drug Application To FDA For Rivaroxaban

Saturday, February 6th, 2010

Johnson & Johnson Pharmaceutical Delving & Development, L.L.C. (J&JPRD) announced that it has submitted a New Drug Application to the U.S. Eatables and Opiate Administration (FDA) with a view rivaroxaban, an investigational, oral, in days gone by-ordinary anticoagulant for the halting of mystical trace thrombosis (DVT) and pulmonary embolism (PE) in patients undergoing hip or knee replacement surgery.

In 2005, J&JPRD entered into an agreement with Bayer HealthCare AG to jointly develop rivaroxaban. If approved by the FDA, Ortho-McNeil, a Division of Ortho-McNeil-Janssen Pharmaceuticals, Inc., at one’s desire deal in the drug in the U.S. Bayer HealthCare holds marketing rights in countries outside the U.S.

Venous blood clots, also known as venous thromboembolism (VTE), categorize DVT - a blood clot in a large vein, usually in the legs - and PE - a blood clot that has traveled to the lungs - both of which are life-threatening but often preventable complications following major orthopedic surgery. Annually in the U.S., more than 900,000 people suffer from VTE events, and 300,000 individuals die from VTE. Patients undergoing hep or knee replacement surgery are at high jeopardize in the course of VTE because the magnanimous veins of the ramshackle that carry blood back to the heart are significantly damaged during these procedures. In experience, venous blood clots occur in up to 40% of patients undergoing vital orthopedic surgery who do not acquire preventative care. Each year, roughly 700,000 Americans elect to have hip and knee replacement surgeries, and a blood clot is the most common cause of re-hospitalization over the extent of this sufferer society.

The filing was supported by details from the global RECORD (REgulation of Coagulation in prime Orthopedic surgery reducing the Chance of DVT and PE) clinical trial program. The REGISTER program involved more than 12,500 patients in four studies and compared rivaroxaban to injected enoxaparin, for the prevention of add up VTE in patients undergoing either total knee or perceptive replacement surgery.

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Johnson & Johnson Pharmaceutical Research & Progress, L.L.C.

Johnson & Johnson Pharmaceutical Investigate & Development, L.L.C. (J&JPRD) is a wholly-owned subsidiary of Johnson & Johnson, the world’s most broadly based organizer of robustness care products. J&JPRD is headquartered in Raritan, N.J., and has facilities fully Europe, the Collective States and Asia. J&JPRD is leveraging pharmaceutical development and drug improvement in a medley of therapeutical areas, including CNS, Internal Medicament and Oncology, to address unmet medical needs worldwide. More information can be establish at http://www.jnjpharmarnd.com.

This press release contains “forward-looking statements” as defined in the Seclusive Securities Legal remedy Reform Act of 1995. These statements are based on coeval expectations of future events. If underlying assumptions prove wrong or unknown risks or uncertainties form, actual results could vary palpably from the Company’s expectations and projections. Risks and uncertainties count widespread industry conditions and striving; economic conditions, such as charge fee and currency exchange merit fluctuations; technological advances and patents attained by competitors; challenges essential in green yield development, including obtaining regulatory approvals; domestic and foreign health take responsibility for reforms and governmental laws and regulations; and trends toward health punctiliousness payment containment. A further roster and report of these risks, uncertainties and other factors can be establish in Exhibit 99 of Johnson & Johnson & Johnson’s Annual Recount on Custom 10-K for the monetary year ended December 30, 2007. Copies of this Propriety 10-K, as well as subsequent filings, are nearby online at http://www.sec.gov, http://www.jnj.com or on entreat from Johnson & Johnson. The Company does not undertake to update any forward-looking statements as a conclude of new dirt or future events or developments.

Johnson & Johnson Pharmaceutical Up on & Development, L.L.C.

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