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Almost three metres of pantihose-coiled DNA strands fit into a cell’s nucleus. As DNA replicates, the strands unwind and expand and then re-package into chromosomes, the genetic blueprints of life - but what happens if this process becomes entangled?

Untangling the heaps of DNA strings during cell division is the work of special enzymes called topoisomerases. How they achieve this feat may be simpler than previously mental activity, says U of T digging. In a study published in the e la mode online issue of Biophysical Roll, researchers tolerant of computer simulations to parodist the DNA intervene inside the heart with a series of billions of linked and unlinked loops. Their calculations indicated that whether DNA molecules are interlinked is shown by the way they touch each other. Interlinked DNA loops tend to touch in an hands down recognizable hook-like way, fitting together perfectly; whereas strands of unlinked DNA molecules tend to curve away when they touch each other. The findings could be enduring implications in designing new drugs to treat cancer and infectious diseases as uncontrolled DNA linking and tangling often result in cell death.

“The heady part is that these seemingly synopsis physical principles we write up with can be salutary some day to make sense up DNA in cancer cells and kill them off,” says U of T biochemist Vexed Sun Chan, the study’s co-author and a Canada Research Chair in proteomics, bioinformatics and serviceable genomics.The study is co-authored by Professor Lynn Zechiedrich of Baylor College of Medicine in Houston, Texas, who proposed the fancy in an earlier conceptual report, and the around to author, Zhirong Liu, is a U of T postdoctoral fellow in Chan’s research group. “These are the unaltered general principles that can be applied to other areas of system and engineering to address various entanglement problems,” Chan says.

The curved distinctions between DNA strands may allow the seamstresses of the dispose of — the topoisomerases — to associate linked DNA loops, commission a strand aside, frustrate another strand pass through, and then reconnect the cut strand so that DNA can separate into untangled lengths that are the chromosomes: the topoisomerases only have to cut and reconnect at hooked-take to but not other touching points. If this approach were disrupted, however, the cell would be in serious skirmishing. “One link could keep the cubicle from dividing. Two links are even more deadly,” says Zechiedrich, who notes that “the results of these computer simulations are very striking.”

While Chan and his collaborators stress their results represent sole a quantitative proof of concept, they do see the finding as unusually relevant object of wisdom diseases such as cancer, where cell multiplication goes haywire. “Besides further elucidating the principles we set up, what needs to be done now is to test these findings experimentally and ultimately refer them to real-living chamber division and target the developmental processes that lead to disease.”

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The retreat was funded by the Canadian Institutes of Constitution Research, the Canada Research Chairs Program, the National Science Underlying, the National Institutes of Health and the Burroughs Wellcome Repository.

The University of Toronto is Canada’s supreme teaching and exploration university and aims to be among the world’s overwhelm. For twelve consecutive years, U of T has taken the top spot magnitude medical/doctoral universities in the annual Maclean’s magazine university ranking. With more than 70,000 students, U of T comprises 28 divisions, colleges and faculties on three campuses. This includes 14 professional faculties, nine fully-united teaching hospitals, numerous research centres and Canada’s largest university library group - the third largest in North America.

http://www.utoronto.ca

Aforementioned studies have shown a connection between health and socioeconomic status (SES), demonstrating higher instances
of kindness sickness, cancer and other evince of poor healthfulness in those lower in the cost-effective scale. The question is why, and how
first in life these effects begin attractive shape.

FINDINGS: Focusing on 18- to 30-year-old study participants, the researchers examined blood glucose, blood pressure
and cholesterol over 10 years to determine how they changed. The findings make one think that individuals with high overall
cardiovascular risk in midlife can be identified by more higher risk factors when they are younger. They found also
that young people from families with a belittle SES well-informed greater increases in those hazard factors than people higher on
the scale. Also, the researchers found that the outcome of SES on risk accumulation is stronger in women than in men, and
stronger in blacks than in whites.

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IMPACT: This is the first about to look at aggregate hazard scores composed of multiple jeopardy factors; to follow changes
in multiple risk factors over 10 years in people in this ripen group; to look at the effects of SES in both pasty and vicious
young adults; to examine the effects of changing one’s SES on overall cardiovascular peril; and the first to find that the
effects of SES on blanket cardiovascular risk in naive adults are not due solely to differences in access to medical feel interest or
in smoking and exercise. Differences in levels of stress in daily life may explain these effects. According to UCLA
researchers, there is expect for people in indecent SES: Improving one’s SES was found to be associated with improvement in endanger
profiles.

AUTHORS: Lead architect is Arun S. Karlamangla, mix professor of medicament in the border of geriatrics at the
David Geffen School of Nostrum at UCLA.

FORTNIGHTLY: Social Science & Pharmaceutical, Vol. 60, No. 5, March 2005. It is also now ready online at
doi:10.1016/j.socscimed.2004.06.056

FUNDERS: National Institutes of Salubriousness (National Institute on Aging and the National Concern, Lung, and Blood
Institute) and the MacArthur Creation

Touch: Enrique Rivero
erivero@support.ucla.edu
310-794-2273
University of California - Los Angeles

Media Contacts:
HHS Press Office:
Campbell Gardett, 202-690-6343
ONDCP: Tom Riley, 202-395-6618
NIDA: Blair Gately, 301-443-6245

Eleven Percent Reduction Exceeds President’s Two-Year Goal

HHS Secretary Tommy G. Thompson and John P. Walters, Commander of National Drug Control Policy, today released results of the 2003 Monitoring the Tomorrow’s survey, showing an 11 percent decline in sedate use by 8th, 10th, and 12th evaluate students over the past two years. The finding translates into 400,000 fewer teen drug users over two years.

When President Bush released his first Public Dull Repress Strategy in February, 2002, he set aggressive national goals to mitigate tad drug use by 10 percent in two years and 25 percent in five years.

Today’s release of the 2003 Monitoring the Future Swotting confirms that President Bush’s two-year goal has been exceeded. Current use (past 30 days) of any illicit numb between 2001 and 2003 among students declined 11 percent, from 19.4 percent to 17.3 percent. Like declines were seen for past year use (11%, from 31.8% to 28.3%) and lifetime function (9%, from 41.0% to 37.4%).

“Teen drug use has reached a level that we haven’t seen in practically a decade” said Vice-president Walters.

“This survey shows that when we overburden back against the downer muddle, it gets smaller. Fewer teens are using drugs because of the deliberate and serious messages they have received about the dangers of drugs from their parents, leaders, and prevention efforts like our National Child Anti-Drug Media Campaign. Having fewer minor use drugs is urgent because we know that if uninitiated people can abstain from drugs before they graduate from high followers, they are much less likely to turn to account and have problems with them later.”

“This survey offers reassuring signs that more children and young adults are steering clear of felonious drugs,” HHS Secretary Tommy G. Thompson said.

“Monitoring the Future confirms that banning efforts by federal agencies, states, communities and our many partners in the private and volunteer sectors are having the desired effect. We are pleased to have exceeded the President’s two-year end and look forward to a continued and needed reduction in drug use in the coming years. We obligation now continue our stride as we quest after to reach the young people who are still putting their health and futures at endanger.”

Use of marijuana, the most commonly used illicit drug among kids, declined significantly. Current use declined 11 percent, from 16.6 percent to 14.8 percent; past year use also declined 11 percent, from 27.5 percent to 24.5 percent; and lifetime permission declined 8.2 percent, from 35.3 to 32.4 percent.

The Nationalist Teen Anti-Drug Media Campaign, a comprehensive federal venture to provide dope prevention messages to America’s children, was reworked in 2002 to produce harder-hitting ads that have focused on the harms of marijuana.

Of the 7.1 million Americans that need cure treatment - 19 percent of which are young boy 12-17 - down 60 percent deprivation treatment for marijuana. The Media Stump has been a influential tool in this effort to educate Americans, particularly teens, on the moment threat marijuana poses.

In addition to measuring usage rates, Monitoring the Future also measures devotee attitudes about drugs. Among all three grades, the perceived danger of using marijuana increased markedly. Peril to anti-drug advertising (of which, the Media Campaign is the chief contributor) has had an effect on improving youth anti-drug attitudes and intentions, Director Walters said.

In the Monitoring study, youth attitudes among all three grades are establish to be to a “great extent” or “very great extent” less favorable toward drugs, and students imply the ads they entertain seen make them less likely to treatment drugs in the expected.

The increase in dissenting attitudes toward drug manipulate corresponds with the despatch of the Media Campaign, launched in 1998. More than half of the grow in these outcomes middle all three grades has occurred in the past two years. This is solely unusual mid 10th graders, the primary objective audience of the Media Drive.

Monitoring the Tomorrow also showed valuable declines in the use of other drugs. The use of LSD and ecstasy among pubescence has plummeted. Lifetime power of LSD knock 43 percent between 2001 and 2003 (from 6.6% to 3.7%) and since year and reported use each dropped by nearly two-thirds (from 4.1% to 1.6% and 1.5% to 0.6%, respectively). Lifetime use of heaven on earth dropped 32 percent, from 8.0 percent to 5.5 percent. Past year and current privilege consumption were each cut in half (from 6.1% to 3.1 percent and 2.4% to 1.1%).

“The overall reduction in slip someone a Mickey Finn use by America’s young people is heartening,” said National Institute of Drug Abuse Director, Dr. Nora Volkow. “We are positive that our concerted feat to provide students and teachers with informative, accurate poop about addiction and drug ill use will forward to more reductions in medicine use.”

“Monitoring the Future has been tracking substance use and interrelated attitudes among American teenagers for nearly thirty years,” said Lloyd Johnston, the study’s lead researcher. “Because its methods have been scientifically rigorous, and intentionally held constant across time, its results have proven to be quite meticulous and reliable.”

In addition, lifetime and flow use of cigarettes declined amid 8th, 10th, and 12th graders between 2001 and 2003. Lifetime alcohol use by all three grades also declined over the past two years, suggesting that teens do not trade one stimulating substance for the treatment of another.

The Monitoring the Future survey is designed to measure drug, alcohol, and cigarette play and tied up attitudes among adolescent students nationwide. Survey participants report their drug use behaviors across three time periods: lifetime, past year, and past month. All-embracing, 48,467 students from 392 public and private schools in the 8th, 10th, and 12th grades participated in this year’s scrutinize.

The inspection is funded by the National Institute on Drug Abuse (NIDA), a component of HHS’ National Institutes of Healthiness, and conducted since its inception by the University of Michigan. Dirt from this scanning helps the nation to identify potential drug problem areas and safeguard that resources are targeted to areas of greatest need.

Monitoring the Approaching is anyone of three notable HHS-sponsored surveys that victual data on burden buy among youth. Its website is http://monitoringthefuture.org.

The Citizen Inquiry on Dose Use and Health (NSDUH), sponsored by HHS’ Property Abuse and Mental Health Services Delivery, is the tutor source of statistical information on illicit dope use in the U.S. population 12 years of age and older.

In the old days known as the Country-wide Household Survey on Drug Abuse, the investigation collects data in household interviews, currently using computer-assisted self-administration as a replacement for drug-related items. More word is available at http://www.drugabusestatistics.samhsa.gov.

The Youth Hazard Behavior Evaluate (YRBS), part of HHS’ Centers for Affliction Control and Prevention’s Youth Imperil Behavior Scrutiny Structure, is a school survey that collects data from students in grades 9-12. The survey includes questions on a wide variety of health-related risk behaviors, not unambiguously drug abuse. More information is available at
http://www.cdc.gov/nccdphp/dash/yrbs/index.htm.

More information on Monitoring the Subsequent can be found at
http://www.hhs.gov/news; or http://www.whitehousedrugpolicy.gov.

Related Material to this Release:
* Monitoring the Future 2003 Fact Sheet [pdf shape 96 Kb]
* Monitoring the Future 2003 Full Press Release on Analgesic Use from the University of Michigan [pdf format 424 Kb]
* Monitoring the Tomorrow 2003 Gorged Press Release on Teen Smoking from the University of Michigan [pdf format 220 Kb]

The National Commence on Narcotize Abuse is a component of the Chauvinistic Institutes of Health, U.S. Department of Well-being and Human Services. NIDA supports more than 85 percent of the world’s inspection on the vigorousness aspects of drug abuse and addiction.

The Introduce carries out a large classification of programs to ensure the rapid dissemination of research info and its implementation in policy and practice. In truth sheets on the health effects of drugs of abuse and besides information on NIDA probe can be originate on the NIDA network site at
http://www.drugabuse.gov.

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MedImmune has announced results from a just out economic dissection of Synagis® (palivizumab), a monoclonal antibody (MAb) that is the habitual of pains for warding of severe debase respiratory article infection due to respiratory syncytial virus (RSV) in high-risk infants. Released at the American Academy of Pediatrics (AAP) 2007 Nationwide Conference & Exhibition, the analysis evaluated the costs of providing Synagis to premature infants, as not unexpectedly as the potential healthfulness benefits and charge savings that could occur from discredit rates of severe RSV infections.

RSV can provoke severe lower respiratory tract infections in preterm infants. However, recent data accept suggested that RSV infection early in an infant’s life may cause aftermath of chronic respiratory complications such as unwavering wheezing.

Dr. Correct Polak, a neonatologist and professor of pediatrics from the West Virginia University College of Drug and margin framer of the economic review, celebrated, “We factored in the potential costs of admissible future complications and the quality of freshness associated with fast wheezing and, based on these assumptions, our study found that preventing RSV betimes in life makes economic sanity.”

The authors noted that more evidence is needed to relief the linkage between Synagis and successive reductions in persistent wheezing.

—————————-
Article adapted by Medical News Today from original press freeing.
—————————-

MedImmune’s Commitment to RSV Tabooing

MedImmune is a world the man in the development of innovative therapeutic biologic products to prevent RSV blight. In 1996, MedImmune launched the initial anti-RSV drug, RespiGam® (respiratory syncytial virus immune globulin intravenous (human) (RSV-IGIV)), which was a polyclonal antibody administered via four-hour intravenous infusion. In 1998, MedImmune introduced Synagis, which was a significant product improvement as a monthly intramuscular injection for the prevention of severe RSV, as well as being the first MAb to receive U.S. Eatables and Dose Oversight (FDA) approval against an infectious cancer. MedImmune continues to shore up its commitment to developing anti-RSV products with the constant development of its next potential anti-RSV antibody, motavizumab, for which the company is planning to submit a Biologic Commission Operation around the beginning of 2008. MedImmune is also developing a small-molecule product candidate to baulk RSV as pleasing as a vaccine against RSV, both of which are in Phase 1 clinical trials.

Back RSV

Each year, up to 125,000 infants in the Harmonious States are hospitalized with aloof RSV infections, the leading lead to of lower respiratory tract infections in U.S. infants. RSV is the most run-of-the-mill respiratory infection in inception or childhood. Take one-half of all infants are infected with RSV during the beginning year of life, and nearing all children have been infected at least once by the culture they reach their second birthday. Children born untimely as very much as those with chronic lung disease (CLD) or congenital sensibility murrain (CHD) are at highest imperil for severe disease and hospitalization due to RSV. The virus may also give rise to autocratic disease in other high-hazard groups.

With reference to Synagis® (palivizumab)

Synagis is the only monoclonal antibody approved by the FDA to help prevent an contagious disease. Synagis is indicated conducive to the prevention of serious lower respiratory tract virus caused by RSV in children at height risk of RSV disease. Synagis was approved against purchase in the United States in 1998, Europe in 1999, and Japan in 2002. Synagis is currently available in 62 countries. The safety and efficacy of Synagis were established in infants with bronchopulmonary dysplasia, infants with a history of prematurity (less than or equal to 35 weeks gestational age), and children with hemodynamically meritorious congenital nerve infection. The firstly dose of Synagis should be administered prior to commencement of the RSV season, which usually starts in the fall and runs through the spring. Patients, including those who develop an RSV infection, should persist in to receive monthly doses throughout the season. Abbott has exclusive rights to Synagis in markets outside the Pooled States. MedImmune promotes Synagis in the Joint States.

Mighty Safety Word

Globally, prescribing information varies; refer to the unique rural area product label for bring to an end low-down. In favour of U.S. safety message, visit http://www.medimmune.com/.

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Sinovac Biotech Ltd. (Amex:
SVA), a unequalled provider of vaccines in China, announced that the
Priesthood of Vigorousness has purchased approximately RMB 20 million (US$2.86
million) of the Company’s inactivated hepatitis A vaccine, Healive(R), to
vaccinate people living in the catastrophe belt following the May 12th
earthquake. Sinovac has delivered shipments of the Healive vaccine to
Sichuan, Shanxi and Gansu provinces.

Mr. Weidong Yin, Chairman, President and CEO, stated, “Sinovac is proud
to provide assistance and vaccines for affliction control to China after the
earthquake. Transmissible disease prevention is particularly high-ranking at this
time in the adversity zone given that the infrastructure to launch clean
wet was destroyed. Sinovac is immeasurably positioned to provide living expenses by
delivering vaccines and knowledge to the disaster region.”

Immediately after the May 12th earthquake, Sinovac donated 50,000 doses
of Healive and a total of RMB 610,000 to Ministry of Health of China to
sponsor affliction control efforts.

About Sinovac

Sinovac Biotech Ltd. is a China-based biopharmaceutical company that
focuses on the research, development, assembly and commercialization of
vaccines that guard against human contagious diseases. Sinovac’s
commercialized vaccines include Healive(R) (hepatitis A), Bilive(R)
(combined hepatitis A and B), Anflu(R) (influenza) and Panflu(TM) (H5N1).
Sinovac is currently developing Universal Pandemic Influenza vaccine and
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FDA does not take adequate vim to guard the safeness of millions of participants in clinical trials, according to a circulate from the HHS Purpose of Inspector General scheduled fitting for release on Friday, the Recent York Times reports.

According to the report, written by HHS Inspector All-inclusive Daniel Levinson, FDA — which oversees trials conducted by companies that seek approval to market medications and medical devices — lacks data on the number of continuous trials, audits less than 1% of crack sites and often performs inspections of the sites after the completion of trials. FDA has 200 inspectors, some of whom audit trials degree time, to inspect about 350,000 sites, the clock in found. In addition, the look into found that FDA officials inclination on the wane serious violations bring about by inspectors at trial sites 68% of the time and that the agency in many cases does not behave additional inspections to determine whether recommended corrective actions occurred.

The report recommended that FDA establish a registry of all ongoing trials, a absolute registry of research ethics boards and a database of inspections of contest sites, as robust as obtain more authority to regulate investigating assistants.

According to some research ethics experts, the problems with FDA oversight of trials cited in the report are, “in tons ways, identical to criticisms leveled at other agency functions, including its heedlessness of imported food, extraneous drug manufacturers, animal sustenance and the safe keeping of older medicines,” as the “size and complexity of the tasks facing the agency have grown enormously as the handful of inspectors for those tasks has generally declined,” the Times reports (Harris, New York Times, 9/28).

Reprinted with kind permission from http://www.kaisernetwork.org. You can opinion the entire Kaiser Quotidian Health Policy Gunfire, search the archives, or sign up against email transport at http://www.kaisernetwork.org/dailyreports/healthpolicy. The Kaiser Daily Health Policy Report is published for kaisernetwork.org, a unshackled services of The Henry J. Kaiser Family Foundation© 2005 Prediction Board Band and Kaiser Family Foundation. All rights reserved.

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The American Institute of Ultrasound in Medicine (AIUM) and the American Syndicate of Clinical Endocrinologists (AACE) announced today a joint agreement on the side of enhancing training, safety, and policies and procedures in ultrasound examinations. In the joint announcement, Dr. Lennard Greenbaum, President of AIUM, said that its Clinical Standards Committee had completed an capacious review of the AACE without a doubt requirements for thyroid/parathyroid ultrasound certification and recertification, and determined that those endocrinologists successfully completing the AACE course resolution be recognized by AIUM as having demonstrated acceptable training in thyroid/parathyroid ultrasound examinations.

AACE President, Dr. Steven M. Petak, said that AACE is pleased to be enduring the progress recognized by AIUM, a preeminent nationalistic ultrasound accreditation fraternity, as having met the educational standards payment quality and patient safety in the performance of ultrasound procedures. AIUM standards serve as a benchmark quest of professionals seeking to run across nationally accepted protocols in performing ultrasound examinations. Dr. Petak said, “Achieving recognition by AIUM destined for conjunction these high educational standards in ultrasound is a tremendous accomplishment, and a clear demonstration of AACE’s commitment to plateful endocrinologists outfit the highest excellence be responsible for in the diagnosis and treatment of their patients with thyroid disorders.”

Dr. Petak added that, since 1998, AACE has conducted a rigorous passage curriculum in ultrasound in spite of endocrinologists performing diagnostic evaluations for patients with thyroid and parathyroid disorders, which includes both diagnostic ultrasonography (US) and ultrasound guided fine needle aspirations (UGFNA). AACE offers this course in order to grant-money physicians in achieving the highest smooth of know-how, clinical skills, and capabilities in the act of US and UGFNA for optimal patient be fond of. Dr. Petak noted that AACE is also pleased to cooperate with AIUM in offering its members the opportunity to participate in the training accreditation program, administered by AIUM, which would enable physician practices to participate in the volunteer show review program to demonstrate competency in all aspects of their ultrasound project, including education and training of physicians in sonography, ultrasound equipment maintenance, document storage, policies safeguarding the patients and personnel, and accuracy in diagnosis.

Dr. Greenbaum pointed out that the two societies’ programs felicitate each other. The AACE physician certification and recertification process want guarantee that endocrinologists have access to progressing training in the latest advances in thyroid ultrasound technology and procedures. Participation in the AIUM practice accreditation program wishes help physicians maintain the highest standards for performing these services in a practice home. “The ultimate beneficiary of the agreement will be the case through enhanced quality and sanctuary in ultrasound procedures,” Greenbaum said.

—————————-
Article adapted by Medical News Today from real put through a mangle issue.
—————————-

AACE is a national expert medical codifying with over 5,500 members in the United States and 84 other countries. Founded in 1991, AACE is dedicated to the optimal care of patients with endocrine disorders. AACE initiatives inform the public about endocrine disorders. AACE also conducts continuing drilling programs for clinical endocrinologists, physicians whose advanced, specialized training enables them to be experts in the care of endocrine blight, such as diabetes, thyroid disorders, growth hormone deficiency, osteoporosis, cholesterol disorders, hypertension and obesity.

AIUM is a multidisciplinary association dedicated to advancing the repository and effective despise of ultrasound in medicine through professional and public education, research, development of guidelines, and accreditation. AIUM’s members include physicians and sonographers from varying specialties, scientists, and engineers. AIUM has established standards with a view the accreditation of ultrasound practices which be serviceable as as a benchmark for professionals seeking to meet nationally accepted protocols for performing ultrasound related examinations. Practices accredited by the AIUM tease demonstrated competency in every aspect of their operation.

Contact: Jennifer Hilderbrand

American Institute of Ultrasound in Medicine

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Entering World Bank President Paul Wolfowitz plans to make Africa the “top priority” of his incumbency, saying that the organization has a “uniquely important role” in “overcoming the troubled continent’s development challenges,” including HIV/AIDS and widespread poverty, the… Be ruined Street Journal reports. “I can’t stress enough how prominent it is that the beforehand importance of the bank is Africa and the poorest people of Africa,” Wolfowitz, who assumes the bank presidency on June 1, said. He added that although he is “aware” of the “large numbers of down people” in Asia and Latin America, Africa is “an space that has been left behind by the amplify that has touched other parts of the world” and that “two important differences” make the continent an “immediate right,” according to the Journal. “In Africa, you play a joke on this array of official discreditable neediness, combined with the most appalling salubriousness conditions,” Wolfowitz said, adding that the “epidemics of AIDS and malaria, which are problems elsewhere,” are “nowhere on the nonetheless scale as in Africa.” Wolfowitz’s comments make public him in “close alignment” with European leaders, who recently have been focusing on “addressing Africa’s recalcitrant problems,” according to the Journal (Hitt, Protection Street Journal, 4/28). British Prime Upon Tony Blair recently formed the Commission in compensation Africa, which in March released a dispatch that aims to put Africa at the forefront of the international agenda during the United Kingdom’s year as seat of the G8 and during its presidency of the European Mixture. The write-up calls for a doubling of international subsidize to Africa to $50 billion annually, the throwing out of trade barriers, debt forgiveness, and increased efforts to address in need governance, corruption and joust with throughout the continent. It also calls as a remedy for funding because of HIV/AIDS to be increased to $10 billion annually within the next five years (Kaiser Daily HIV/AIDS Describe, 3/14).

Development Aid, Debt Relief
Wolfowitz also suggested that the World Bank might increase funds directed to Africa, according to the Journal. As of June 30, 2004, the bank had $16.6 billion in outstanding loans and grants to sub-Saharan African countries, most of which are 40-year, interest-free loans. The United States and other wealthy nations also provide billions of dollars in direct aid annually, the Journal reports (Wall Street Journal, 4/28). Finance ministers from the Group of Seven industrialized nations, the World Bank and the International Monetary Fund earlier this month at their biannual meeting in Washington, D.C., also pressed ahead with efforts to forgive the debt of the world’s poorest nations — including those in Africa — saying that they hope to come to an agreement later this year (Kaiser Daily HIV/AIDS Report, 4/18). However, Wolfowitz said any “comprehensive solution” would include not only debt relief and increased aid but also would address how to prevent corruption, strengthen governmental commitment to transparency and accountability, develop the private sector and promote trade by opening world markets. “I do think making more resources available has definitely got to be part of the answer, but it takes more than that,” Wolfowitz said. He added that it would be “presumptuous to assume” that his connections to the White House could “benefit” the bank, according to the Journal. However, his role as former U.S. deputy defense secretary “inevitably” will “present opportunities,” and Wolfowitz has said that President Bush is “already open to the development agenda,” the Journal reports (Wall Street Journal, 4/28).

“Reprinted with permission from kaisernetwork.org kaisernetwork.org. You can view the entire Kaiser Daily HIV/AIDS Report, search the archives, or sign up for email delivery at www.kaisernetwork.org/dailyreports/hiv.. The Kaiser Daily HIV/AIDS Report is published for kaisernetwork.org, a free service of The Henry J. Kaiser Family Foundation . © 2005 Advisory Board Company and Kaiser Family Foundation. All rights reserved.

When you’re in your local dispensary, do you ever shot to analogize resemble the lables on products, only to find that the print is impossible to read? A new study goes a petty way to remedy this, at least also in behalf of those who are visually impaired. The study found that the information and instructions provided with medicines is far too small for people with impaired or relatively sighted vision to read. The findings are reported in the simultaneous issue of the British Weekly of Ophthalmology.

Most information on medicines and treatment is communicated in writing, but little thought has been given as to whether patients can actually read it, say the authors.

According to the World Health Organisation, levels of visual impairment range from 1 in 1,000 to 1 in 10, depending on the age group

They assessed the point at which 180 patients stopped being able to read, without magnification, the manufacturer’s printed instructions on the side of a bottle of eye-drops.

All the patients, whose average age was 70, had impaired eyesight in one or both eyes, to varying degrees. This included a range of conditions, including glaucoma, macular degeneration, and cataract.

The patients were allowed to bring the bottle as close to their face as possible in order to read it, and if they were able to do so, the time it took them was recorded. More than 30 seconds was classified as “reading with great difficulty.�

They were then asked to select the type and type sizes they found easiest to read.

Patients with moderately good sight, designated as 6/18 visual acuity, were able to read the instructions, but around two thirds of those with poorer sight in the range 6/24 and 6/36 were unable to read them. And almost all of those with 6/60 visual acuity could not read them.

Unsurprisingly, the more difficulty patients had deciphering the instructions, the larger type size they preferred, but the authors say that an enlarged font of Arial 22, which is about three times the size normally used, would meet everyone’s needs.

The authors say that this overlooked aspect of care is important, because patients need to be able to take the right and safe dose of medicine.

“It is common for patients to leave a consultation without remembering what was discussed, including how to take their medication,� they say, adding that the problems can be compounded for those who are hard of hearing or whose memory is impaired.

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